The biggest shortcoming of the classic Amiga was the inability to read/write HighDensity floppies, which are standard in the PC world. Another one was not supporting IDE harddisks early enough. Third one too late support for VGA-monitors. These three reasons were propably the most significant ones that stopped Amiga becoming the world leader in computers today.
I remember reading an interview from a Sierra-onLine executive back in the day where he said that when hard drives become standard for all new amigas they would restart production of game ports... but C= management was still asleep....