@mbrantley
It has been a long time since I installed TVPaint. I had AmigaOS 4.0 at that time and I did not know how to mount an ADF file, so I used AmigaOS4 PPC version of E-UAE and AmigaOS 3.1 to emulate a Classic Amiga. I installed TVPaint using OS 3.1 then quit E-UAE, went back to OS4 and moved the TVPaint drawer out to a more convenient location on my OS4 partition.
Ever since then, I have run TVPaint directly under OS4 (with no E-UAE) with no problems at all. Now working fine with OS4.1 Update 2.
If I recall correctly you might have to save a config file. If you copied TVPaint from another computer you might have to delete the config file and save a new config file the first time you run TVPaint.
On my system, there is a TVPaint.config file located in the Prefs:env-archive drawer.
There is also a file called TVPaint.ini in the TVPaint drawer. If you rename this file to something else, it might allow you to make some changes.
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redfox