I'm running WHDLoad (demos mostly) on an A4000 with CSmk1 060.
From my experience with a few hundred demos and games, about 50% run, some with glitches here and there.
The other 50% require lots of massaging, playing around with tooltips etc, but that doesn't always help.
Its mostly old slaves that have issues.
I've recently built a basic KS1.2 A500 with a Gotek, just for running all the old stuff without hassle or glitches.