Sure it makes sense:
-You can run native amiga modes on RTG (in cases you don't have a scandoubler/monitor switcher)
-You can mount CAPS images (in case you don't have a PC with WinUAE)
-You can run a game without waving to reset or close apps that cause interrupt problems.
-You may just try it ( for fun:-D )
Speedwise now:
I mentioned the WOS version of plain UAE because it runs nicely for simple games/demos on a PPC604e@150 here.
Unfortunately, it lacks a decent GUI, and the tweaking you can easyly do with WinUAE, (you still have to edit by hand the text file -not very intuitive- ).
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California Dispensary