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The chief advantage I see would be the fact that they're small enough to not require any workarounds (e.g., the various patches to prep/use drives larger than 4GB). But the same can be accomplished these days with 4GB CF cards and an IDE adapter. The only thing to maybe consider is whether the CF card will hit its maximum number of write cycles before a traditional hard drive dies of mechanical failure. I'd say that's not very likely to happen. I'm using CF cards as hard drives in several of my machines and I'm soon going to convert my primary Amiga system to use one as well.
