I managed to go through several Amiga models without much of a problem.
However...

I had bought a brand new A1200 (this was when they first came out). It was too much of a pain to get a real 2.5'' HD at the time so I opted for a 3.5'' external HD box. It included a special cable that connected to the A1200's internal 2.5'' IDE hearder. So everything went fine and dandy. There were a few times when I reorganized my room and moved the A1200, A2000 around. Then, one faithful move, I plugged the cable in backwards. This wouldn't be a BIG deal with most IDE connectors, except that this special cable had power running on some of the pins...
So I plug everything in and "poof" the A1200 refused to boot up anymore. Luckily all I ended up doing was frying my HD. Unfortuantly, a "cartoonist" friend of mine was working on a picture with deluxe paint on my system and it got lost.