Well you said above that you can boot other disks, and assuming you mean floppies, then I'd doubt it is the drive itself. I know that if it only this one disk, then there has to a cause related to that disk; what does this do that others don't? Boot from your HDD and check the disk directory; if you can't read the directory then it doing something wonky and setting up its own OS. Other ways of checking it would be to see if it can be copied with or without one of the nibble copiers. Sometimes a sector editor will give you a hint. Or try Dave Haynie's DiskSalv and see what errors it brings up (don't let DiskSalv try to repair a game disk, as it will be ruined). If all else fails get some else's copy of the disk to check on your system. There are out there cracked copies of disks, but we all know not to talk about them (yep, it's there in several versions that have been hacked).