I'd like something very simple; a 25pin serial to USB cable to connect my Amiga to a modern computer.
This already kind of exists as two separate cables with a USB<->RS232 adapter in the middle, but I'd rather get something more elegant.
This is something that could easily use the same plastic shell as a parallel<->USB printer adapter, (so there's no need to make any expensive new injection molds), and an existing (and well supported) USB<->RS232 chip.