Really? I'd have thought that tables, properly applied (and by "properly applied" I mean "used to organize tables of information, and not as a poor man's layout tool,") would if anything be an aid to specialty readers...
Listen to Karlos. There are so many benefits from keeping the content separated from the layout/graphical design, you do that in CSS. Tables are not evil per se, they are great at what they are meant for — presenting a set of data in the shape of a table with columns and rows. But using tables for layout and graphical design in a web page is as kosher as using rolled up tin-foil as electric cabling when building a new house, or using glued together straws from McDonalds as your plumbing. Even if it might work, you simply don't do that, even the thought is insane, and has been so for a *veeery* long time now...