I've used a couple with Zip drives and CD-ROMs, worked fine. But I cannot vouch for how well they work with hard drives. I would assume that they should work fine, considering.
You might want to make sure you are using ones which terminate the unused lines. I have used ones which I pulled from narrow tape drives installed in Dell servers with 68-pin SCSI, made by Datamate. They work in both directions, too: I have one in a narrow SCSI controller in a Sun IPX Station running a Western Digital 9GB 68-pin drive.