Err well This is more a function of the 68000. They were similar to the A1000/A500/A2000. They could only address 8 megs with a 24 bit memory space. Unfortunately, doesn't this sound familiar.
Most of the really early ones could only be expanded to 4 megs on the motherboard. The mac SE (for example) could go to more if a 68030 accelerator was added, (again a function of the 68030 rather than the mac itself.)
A 24bit address scheme should be able to address 16 megabytes.
Not that its vital, since most of my early 68K systems couldn't handle more than 4MB either, ram was expensive.
But I'm fairly sure I remember at least one Mac model that wasted half the addressing capability.
As far as accelerators go, I've always wondered how they addressed tying in the ram to the rest of the system since DMA and other functions would be easily available.
AND, outside our little diversion, I'm glad to see the Vampire applied to boards outside the Amiga.
There are lots of applications that could benefit from this device.