Deluxe Paint -The Defacto pixel editor for many years, used heavily in the video games industry and still gets copied on the PC now.
Cinema 4D - Still a major player in 3D packages.
Lightwave - Babylon 5, Seaquest, Robocop TV series etc.
Populous - The first god game.
Sound tracker -Trackers and MOD's are still being created, and the portable game systems still use trackertunes for music.
Directory Opus -still going, and several clones have been created for other platforms.
AMOS - a precusdor to click and play, dark basic etc.
TV paint -was used for a lot of TV work.
Workbench/Intuition
Hello BeOs, i'm looking at you.
LZX -used for microsoft CAB files, I think.
IFF format. I think googles new image format is an IFF derivitive.
erm, that'll do for now.