I have always used DMS to the hard drive. Floppy sets get stored in drawers. mkisofs the main store, then burn that ISO to CD or DVD using my Solaris or Windows box, using good media. On the Solaris box I use a 12/24GB tape to back up the ISO images, or the raw files. Then I wind up with about four copies of what I had before. Now that CF cards are so inexpensive, as are USB sticks, there's more media on which to store my treasure troves.
In the past I used Zip disks. I actually started making backups of my 1581 and 1541 disks as .d64 and .d81 (or just a right file copy using FD0: device on 1581 disks.)
I work with Sendmail a lot and I remember one time reading someone say that Sendmail's strength is its unlimited configurability, and Sendmail's weakness is its unlimited configurability. I see Amiga as much the same... so many choices!
