Everyone notices the lag and/or slowness of WinUAE when playing Total Chaos AGA. I know because I am the one who has to listen to their zillions of complaints.
Everyone notices when games and utils crash while JIT is on.
Many people, such as myself, notice the laggy input when emulating AGA. If you own a fearsomely powerful bgcPC, there is always a delay of 1/50th second or more when moving the mouse or typing. Its quite annoying. If you own a "regular" bgcPC the delay is more, around 3/50th of a second or more. Really unusable.
This is why I am rewriting the game and porting it to WinUAE.