No, nothing was added to my WEStartup drawer in years. It is fully loaded. GVP Accelerator/SCSI card, SD Reader/writer, Floppy, HD and CD Rom. Nothing was changed at all. One day, I turned it on and the mouse would not work at all.
Today, I swapped out the CDROM becuase the door keep opening and closing repeatedly. After swapping it out, the mouse came back but all the Drives and drawers don't open. The mouse just remains as as if busy (displaying stopwatch icon).
Quiksanz has a good idea. I will put a jumper on the accelerator and disable the scsi and see what happens. It may definitely be a bad HD. That puppy is pretty old.
Also, no new peripherals were added or removed, so something currently installed went bad. Either a chip or HD, etc.