I have a SoundBlaster X-Fi that works with Deneb. It's a pretty fancy card with a nice DAC, but with USB audio, you still need a really fast processor. Compared to a modern computing experience, I really was not impressed using USB for audio even when I had an 060 in my A2500. Computer slowed to a crawl when in use. Perhaps you'd have better luck with Zorro III mode in the A4000. At this point though, I think I'd pursue a Sunrize AD516 if I cared about 16-bit audio on an Amiga today. A lot better performance IIRC.
Oh and to date, there is no support for Wireless USB dongles. The guy behind Poseidon (Chris Hodges) mentioned there will probably never be either.