In Amiga OS 4.1 terms yes.
The Games that work with the older Amiga OS 4.1 machines and Radeon 7000 series and Radeon 9000 series cards and Warp3D now work on the newer machines with the Radeon HD 2D and 3D drivers with the supported Radeon HD SI cards. previously you had to use a Radeon 9200 series pci card in your X1000 for hardware 3D support.The results with the PCI card were not the best .
But, do any games exist to take advantage of it?