id like to help :-)
AmigaOS does need a good up to date reference that is compareable to RKRM's
If you like I might start with Intuition, Graphics, Gadtools and Reaction.
probably Intuition, and IDCMP msg handling - user interface stuff
start from the more essential things and work your way out
...you might find that the last thing you focus on is layers.library perhaps :-P