If you have 32 megs of Fast RAM, you'll probably be able to install your wadfile to the RAM disk and run it from there. Here's how: First you rename doom.wad to doom.wadd. Make a softlink that points to ram:doom.wadd named doom.wad. Set up a script to copy the doom.wadd file to RAM: before you start the game.
This technique has a few advantages besides eliminating hard drive accesses to the wad file while you are playing. If you had copied the whole directory structure to RAM: you'd lose your savegames every time you'd power down the system. Also, this technique lets you keep more memory available than if you copied everything to RAM: .