No, the 318069-10 variant (as used in A500+) has a different pinout, making it incompatible with A500/A2000.
You can instead use the 8272A Agnus (NTSC/PAL selectable via JP4 - open for PAL, 1MB).
Or you can use the 318069-16 variant of the 8375, which has a mostly compatible pinout with the A500, but you need to perform
this modification. J102 as referenced in that document is JP4 in the A500, and there is no R101 to remove in the A500.
And you need to replace the 28.636MHz oscillator module with 28.375MHz.