I'm going to say something probably pretty dumb and obvious here, but have you tested out the mouse on another system? Have you tested the system with a different mouse? Can you confirm the mouse is working well? Otherwise yes, probably those fuses!
Yeah, I should have gone there first too.
So like Mike says, start with the mouse itself.
Check the fuses.
Then swap the CIAs and see if it changes the symptoms.
It's very rarely worse than that.