As for CDROM/DVDROM, there's plenty of software that benefits from it. Quake, Descent FreeSpace, Nightlong, Naplam, Tzero, Earth 2140, Trapped1/2, Beneath A Steel Sky, ScummVM games, Amiga Dev CD, OS3.5/3.9, Simon The Sorceror 1/2, Feeble Files, Payback, F1 Licensware PD, AMOS PD CD, Ultimate Blitz, Aminet Collections, to name a few that I have myself, and there's plenty more out there.