-The MacroSystem´s DraCo has five Zorro II slots that operate at twice the speed of the traditional Amiga Zorro II slots and can make use of most of the Zorro II cards that were made.
So yes, it can be done.
Running zorro 2 at double the speed would involve doubling the speed of dma as well, which would also include fast ram on the cpu bus. By the time the double speed clock has spread that far round the A2000, you're running the risk of having to do something special to make it avoid hitting the cia/agnus/paula etc. You may hit problems with buster or the way the motherboard is designed. The former could be solved by creating a new buster chip, the later would require something like an "a2000 reloaded".
The draco just proves that you won't have too many problems with the cards.