You might want to try the Portaudio plugin which gives Winuae access to low latency ASIO. Just place it in the root of your Winuae directory and then select it PA: ASIO from Winua sound settings.
information here:
http://eab.abime.net/showthread.php?t=42566I use it myself, and it has enabled me to set the buffer in Winua to 1 with no skipping! Works well.
