I'm in the process of rewiring a Sega Mega Drive controller to use with my Amiga. As it is now, I can use button B and C on the controller (Button 1 and Button 2 on the Amiga) without further modifications. I'm thinking of rewiring so C is Up. Good for games with jumping. I prefer to have the jump button on the right side of the fire button (I'm an old NES player!). This would be easiest but I would loose one button.
That's the background, now for the question. Most game as far as I can remember only supported one joystick button and Up was commonly used for jumping in platform games. Did any game support multiple buttons, and if so, which games?