Not really. It simply depends on the monitor driver you're using.
I remember when I first got OS4 back in 2004. I'd had the A1 for about a year and was using a 14" Acer monitor I'd borrowed from my brother. Linux had restricted me to a max of 800x600 so when I got play with P96 I decided to try and push out the max resolution of 2048x1536 just for fun. Amazingly it worked, it was as flickery as hell and totally unusable due to the small size of everything on that tiny 14" screen.
I think I settled for for 1024x768* proudly telling myself that Amiga was way better than Linux.
Now I use a 24" LCD at 1920x1200 and can't really imagine going back to tiny screens with low resolutions for Workbench use.
*maybe even 1280x1024, I know that I was able to get a stable image at higher resolutions than the Debian installer had made available to me.