Ok, a few things:
When you open a thread, the focus jumps to the bottom of the thread, quite annoying, imho.
Ah, apparently that only applies when accessing them from the front page, I guess I can live with that Also, the comments to news items insist on showing up in the "threaded" view, even though I chose "flat" in my profile.
Other than a few fonts that look a bit large, I have no major gripes with the new look, I'm sure it will be revised as we go on
---edit---
Funny little thing, i didn't remember appending those three dots in the end of my signature, so I removed them ... or so I thought, they seem to have come back ... o_O